Senyawa Daun Rasamala (Altingia excelsa Nornha) sebagai Penghambat Proliferasi Sel Kanker Lidah Manusia In Vitro
(Rasamala Leaves Compound (Altingia excelsa Nornha) as an Inhibitor of Human Tongue Cancer Cell Proliferation in Vitro)
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Risyandi Anwar
Bagian Ilmu Kedokteran Gigi Anak, Fakultas Kedokteran Gigi Universitas Muhammadiyah Semarang
Arlette Setiawan
Bagian Ilmu Kedokteran Gigi Anak, Fakultas Kedokteran Gigi, Universitas Padjadjaran
Supriatno
Bagian Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Gajah Mada
Unang Supratman
Jurusan Kimia, Fakultas matematika dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
DOI: https://doi.org/10.19184/stoma.v16i2.23090
ABSTRACT
Tongue cancer is a common malignant in the oral cavity and to now medically succes its no good so often treated of life. The aims of study were to identify the secondary matabolities of Rasamala leaves, to examine the compound of Rasamala leaves toward SP-C1 cell growth inhibition. True experimental laboratories design using SPC1 oral tongue cancer cell line was used. The ethyl acetate extract was separated their secondary metabolites by various chromatographic techniques guided by antiproliferasi activity to yield five compounds, as 3,4-dihydroxy benzoic acid (1), gallic acid (2), and apigenin (3). Compounds 1-3 were tested on their antiproliferative activity against cancer cells tongue SP-C1 and showed IC50 values of  100,  100, and  100 μg/mL, respectively. Data analysis using ANACOVA assay, Tukey HSD with the level of significance α=0.05. In conclusion, compound from Rasamala leaves have a strong anticancer activity in human oral tongue cancer SP-C1 through inhibit cell prolieration.
Published
10-10-2019
Issue
Vol. 16 No. 2 2019: Jurnal Stomatognatic
Pages
42-48
License
Copyright (c) 2019 Jurnal Stomatognatic
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