Hubungan Kadar Insulin Pankreas dan Kadar Glukosa Darah pada Model Tikus Wistar Jantan setelah Diinduksi Bisphenol-A
(The Relation of Insulin Pancreas Levels and Blood Glucose Levels to Wistar Rat Models After Bisphenol-A Induction)
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Mala Hayati
Fakultas Kedokteran Gigi, Universitas Jember
Zahreni Hamzah
Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember
Ari Tri Wanodyo
Bagian Ilmu Kesehatan Gigi Masyarakat, Fakultas Kedokteran Gigi, Universitas Jember
DOI: https://doi.org/10.19184/stoma.v17i1.23606
ABSTRACT
This study was to determine the relation between pancreas insulin levels and blood glucose levels in male wistar rat models after Bisphenol-A induction. This research was a laboratory experimental study with a randomized separate pretest-post test control group design. The samples consist of 12 rats that divided into 2 groups. Each group consist 6 rats. In the treatment group, bisphenol-a is given peroral at a dose of 20mg/ kg for 28 days. Pancreas insulin levels will be examined by ELISA and blood glucose levels measurement done by glucometer before decapitation procedure. The data were analyzed by Pearson correlation test for blood glucose levels and pancreas insulin levels (p <0.05). The results showed r count (0.802), sig. 2 tailed (0.002), which mean there is a strong correlation and a positive relation between pancreas insulin levels and blood glucose levels. The higher the pancreas insulin levels, the blood glucose levels will also increase. There was a strong correlation and a positive relation between pancreas insulin levels and blood glucose levels, which is when pancreas insulin levels elevated, blood glucose levels will also be increased in BPA-induced rat with dose of 20 mg / kg / day for 28 days.
Published
16-3-2020
Issue
Vol. 17 No. 1 2020: Jurnal Stomatognatic
Pages
4-7
License
Copyright (c) 2020 Jurnal Stomatognatic
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