Efektivitas Gel Esktrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) terhadap Penyembuhan Ulser Pada Tikus Wistar
(The Effectiveness of Pandan Wangi (Pandanus amaryllifolius Roxb.) Leaf Extract Gel on Ulcer Healing in Wistar Rats)
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Mahardiani Dwi Astanti
Fakultas Kedokteran Gigi Universitas Jember
Pujiana Endah Lestari
Bagian Mikrobiologi Fakultas Kedokteran Gigi Universitas Jember
Iin Eliana Triwahyuni
Bagian Penyakit Mulut Fakultas Kedokteran Gigi Universitas Jember
DOI: https://doi.org/10.19184/stoma.v19i1.30693
ABSTRACT
Ulcer is a lesion that is often found in the oral cavity that causes discomfort, pain, difficulty speaking and difficulty eating. Nowdays, herbal ingredients are widely used as alternative medicine choice besides drugs on the market. Pandan leaf contains flavonoids, alkaloids, saponins, and polyphenols which have antiinflammatory, antibacterial, and antioxidant abilities, allowing faster healing of ulcers. Purpose of this study was to determine the effect of pandanus leaf extract gel on healing ulcers and determine the most effective concentration in healing ulcers. This study used25 Wistar rats divided into 5 groups, which were applied CMC-Na gel, aloclair gel, 25%, 50% dan 75% pandan wangi leaf extract gel. Each rat was made ulcer by heating the stopper amalgam on the bunsen fire for 30 seconds, then touching to the left buccal mucosa for 1 second, and waiting for 2x24 hours to form an ulcer. Giving the gel every morning and evening and measure the diameter of ulcers every day. This study showedhealing time and decrease ulcer diameter pandanus leaf extract gel faster than negative control. The average recovery day was negative control for 9.8 days, positive control for 8 days, pandanus leaf extract gel concentration 25% for 8.6 days, concentration 50% for 8 days, and concentration 75% for 6.8 days. Pandan leaf extract gel accelerated ulcer healing and 75% concentration is the most effective.
Published
2022-03-31
Issue
Vol. 19 No. 1 2022: Jurnal Stomatognaticic
Pages
7-12
License
Copyright (c) 2022 Jurnal Stomatognatic
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