Dwi Merry Christmarini Robin

Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember, Indonesia

DOI: https://doi.org/10.19184/stoma.v21i1.47342

ABSTRACT 

Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative condition that affects the temporomandibular joint, causing pain, stiffness, and limited jaw movement. Conventional therapies such as medications, physical therapy, and surgery often  only  provide  temporary  solutions  and  cannot  permanently  restore  joint  function.  Therefore,  regenerative  therapy  has emerged as a promising approach to address TMJ OA by harnessing the body's natural healing potential. This literature review aims to provide a comprehensive overview of the development of regenerative therapies for TMJ OA, including therapeutic strategies, challenges, and future opportunities. Regenerative therapies for TMJ OA encompass various strategies, such as stem cell  injections,  biomaterial  scaffolds,  growth  factors,  gene  therapy,  and  combination  therapies.  Although  regenerative therapies have shown promising results in preclinical studies, several challenges remain, such as safety, efficacy, and translation into  clinical  applications.  It  can  be  concluded  that  regenerative  therapy  offers  an  innovative  and  potential  approach  to addressing TMJ OA by utilizing the body's natural healing capabilities, with the hope of restoring joint function and improving the quality of life for TMJ OA patients in the future.