Peningkatan Kadar Serum Trk-B Akibat Latihan Fisik di Bawah UV-B dan Diet Minyak Ikan pada Tikus Wistar
(Increased Serum Trk-B Levels Due to Physical Exercise Under UV-B and Fish Oil Diet in Wistar Rats)
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Zahreni Hamzah
Departemen Biomedik dan Patologi Mulut dan Maksilofasial, Fakultas Kedokteran Gigi Universitas Jember, Indonesia
Tantin Ermawati
Departemen Biomedik dan Patologi Mulut dan Maksilofasial, Fakultas Kedokteran Gigi Universitas Jember, Indonesia
Musa Janka Dausat
Fakultas Kedokteran Gigi, Universitas Jember, Indonesia
DOI: https://doi.org/10.19184/stoma.v22i2.53744
ABSTRACT
Ageing is a complex biological process involving systemic changes in body structure and function, including serum Trk-B for improved cognitive function. Declining cognitive function during ageing is often caused by reduced vitamin D production due to UV-B exposure. A combination of physical activity under UV-B exposure (ORUV) and a fish oil diet is expected to improve cognitive function. This study aims to evaluate the effect of physical exercise under UV-B exposure and consumption of lemuru fish oil diet on increasing Trk-B levels in cognitive function. This study was conducted experimentally in an animal laboratory using male Wistar rats weighing between 250-350 grams and aged 3-4 months. Observations were made on days 0, 14, and 28. The rats were divided into three groups (n=4): the control group (K0, K14, K28), the physical exercise group with UV-B exposure (ORUV), and the group given fish oil supplementation (OM) 1.5 ml/day. The results were tested for differences using ANOVA with SPSS ver 26. Statistical tests showed significant differences (p < 0.05) between groups. However, significant differences were found between K0 and ORUV14, K14 and K28, OM14 and OM28, and between OM14 and ORUV28. The combination of physical exercise with UV-B exposure and fish oil diet significantly increased TrkB levels. The combination of exercise with UV-B exposure and fish oil diet (OM) has been proven to complement each other in increasing serum Trk-B levels, so that the combination of the two can activate the BDNF/Trk-B pathway to support neuroplasticity, which has the potential to prevent cognitive and oromaxillofacial function decline, so that it can be considered as a strategy to maintain brain health and oromaxillofacial function in the elderly.
Published
31-10-2025
Issue
Vol. 22 No. 2 2025: Jurnal Stomatognatic
Pages
154-160
License
Copyright (c) 2025 Jurnal Stomatognatic
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