Uji Perbandingan Potensi Efek Antiinflamasi Larutan Deksametason 0,01%, Klorheksidin Diglukonat 0,2%, dan Campuran Deksametason 0,01% dengan Klorheksidin Diglukonat 0,2%
(Comparative Study of The Anti-inflammatory Effects of 0.01% Dexamethasone, 0.2% Chlorhexidine Digluconate, and a Combination of 0.01% Dexamethasone with 0.2% Chlorhexidine Digluconate)
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Nathasya Angeliq Chandra Wijaya
Fakultas Kedokteran Gigi, Universitas Kristen Maranatha, Indonesia
Theodora Adhisty Dwiarie
Bagian Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Kristen Maranatha, Indonesia
Shelly Lelyana
Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Kristen Maranatha, Indonesia
DOI: https://doi.org/10.19184/stoma.v23i2.60025
ABSTRACT
Oral inflammation is a natural body response to tissue damage commonly caused by trauma, irritation, or infection. Corticosteroids are used as anti-inflammatory agents, while chlorhexidine digluconate functions as an antiseptic. The combination of dexamethasone and chlorhexidine digluconate in a mouthwash formulation is still rarely found; therefore, its anti-inflammatory potential needs to be evaluated. This study was conducted to compare the potential anti-inflammatory activity of 0.01% dexamethasone, 0.2% chlorhexidine digluconate, and the combination of 0.01% dexamethasone with 0.2% chlorhexidine digluconate. A true experimental in-vitro study with a pre-test and post-test control group design was evaluated using the albumin denaturation assay to evaluate anti-inflammatory activity. Data were analyzed for normality and homogeneity, followed by One Way ANOVA. Dexamethasone 0.01% exhibited the strongest anti-inflammatory effect compared to the combination of dexamethasone with 0.2% chlorhexidine digluconate. Nevertheless, the combination still demonstrated measurable anti-inflammatory activity. The combination of dexamethasone and chlorhexidine digluconate shows potential as an anti-inflammatory with additional antiseptic benefits, although it does not enhance the anti-inflammatory effect compared to dexamethasone alone. These findings are limited to an in vitro albumin denaturation assay, and further studies are required before clinical application can be considered.
Keywords: Albumin denaturation, Anti-inflammatory, Chlorhexidine digluconate, Dexamethasone, Mouthwash.
Published
30-10-2026
Issue
Vol. 23 No. 2 2026: Jurnal Stomatognatic
Pages
143-149
License
Copyright (c) 2026 Jurnal Stomatognatic
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